Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

Aims To evaluate the antimalarial agent quinine as a potential in vivo probe for hepatic cytochrome P450 (CYP) 3A4 activity. Methods Ten healthy adult volunteers received, by randomized crossover design, either a single oral dose of quinine sulphate (600 mg) alone, or quinine sulphate (600 mg) plus...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Wanwimolruk, Sompon, Paine, Mary F, Pusek, Susan N, Watkins, Paul B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Ltd 2002
Soggetti:
Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874504/
https://ncbi.nlm.nih.gov/pubmed/12492613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01687.x
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi