Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed hepatocytes can trigger immune responses that may be common acr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Sci
Prif Awduron: Holman, Natalie S., Mosedale, Merrie, Wolf, Kristina K., LeCluyse, Edward L., Watkins, Paul B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Extracellular Vesicles and Drug-Induced Liver Injury
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880137/
https://ncbi.nlm.nih.gov/pubmed/26962055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw047
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