miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in an adaptive immune response begins with drug-induced hepatocyte stress, release of exosomal danger signals,...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Mosedale, Merrie, Eaddy, J Scott, Trask, O Joseph, Holman, Natalie S, Wolf, Kristina K, LeCluyse, Edward, Ware, Brenton R, Khetani, Salman R, Lu, Jingtao, Brock, William J, Roth, Sharin E, Watkins, Paul B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
EXOSOMAL RELEASE OF microRNA-122 IN TOLVAPTAN-INDUCED TOXICITY
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257010/
https://ncbi.nlm.nih.gov/pubmed/29029277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx206
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