miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in an adaptive immune response begins with drug-induced hepatocyte stress, release of exosomal danger signals,...

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Publicat a:Toxicol Sci
Autors principals: Mosedale, Merrie, Eaddy, J Scott, Trask, O Joseph, Holman, Natalie S, Wolf, Kristina K, LeCluyse, Edward, Ware, Brenton R, Khetani, Salman R, Lu, Jingtao, Brock, William J, Roth, Sharin E, Watkins, Paul B
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
EXOSOMAL RELEASE OF microRNA-122 IN TOLVAPTAN-INDUCED TOXICITY
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257010/
https://ncbi.nlm.nih.gov/pubmed/29029277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx206
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