miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in an adaptive immune response begins with drug-induced hepatocyte stress, release of exosomal danger signals,...

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Udgivet i:Toxicol Sci
Main Authors: Mosedale, Merrie, Eaddy, J Scott, Trask, O Joseph, Holman, Natalie S, Wolf, Kristina K, LeCluyse, Edward, Ware, Brenton R, Khetani, Salman R, Lu, Jingtao, Brock, William J, Roth, Sharin E, Watkins, Paul B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
EXOSOMAL RELEASE OF microRNA-122 IN TOLVAPTAN-INDUCED TOXICITY
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257010/
https://ncbi.nlm.nih.gov/pubmed/29029277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx206
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