Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed hepatocytes can trigger immune responses that may be common acr...

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Bibliografiset tiedot
Julkaisussa:Toxicol Sci
Päätekijät: Holman, Natalie S., Mosedale, Merrie, Wolf, Kristina K., LeCluyse, Edward L., Watkins, Paul B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2016
Aiheet:
Extracellular Vesicles and Drug-Induced Liver Injury
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880137/
https://ncbi.nlm.nih.gov/pubmed/26962055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw047
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