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Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed hepatocytes can trigger immune responses that may be common acr...

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Podrobná bibliografie
Vydáno v:Toxicol Sci
Hlavní autoři: Holman, Natalie S., Mosedale, Merrie, Wolf, Kristina K., LeCluyse, Edward L., Watkins, Paul B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880137/
https://ncbi.nlm.nih.gov/pubmed/26962055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw047
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