Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed hepatocytes can trigger immune responses that may be common acr...

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Bibliografische gegevens
Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Holman, Natalie S., Mosedale, Merrie, Wolf, Kristina K., LeCluyse, Edward L., Watkins, Paul B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
Onderwerpen:
Extracellular Vesicles and Drug-Induced Liver Injury
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880137/
https://ncbi.nlm.nih.gov/pubmed/26962055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw047
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