Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury

Most idiosyncratic drug-induced liver injury appears to result from an adaptive immune attack on the liver. Recent evidence suggests that the T-cell response may be facilitated by the loss of immune tolerance. In this study, we explored the hypothesis that constitutively released hepatocyte-derived...

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Detalles Bibliográficos
Publicado en:Toxicol Sci
Main Authors: Holman, Natalie S, Church, Rachel J, Nautiyal, Manisha, Rose, Kelly A, Thacker, Sarah E, Otieno, Monicah A, Wolf, Kristina K, LeCluyse, Edward, Watkins, Paul B, Mosedale, Merrie
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Molecular, Biochemical, and Systems Toxicology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657666/
https://ncbi.nlm.nih.gov/pubmed/31093666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz112
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