Evaluation of the Endothelin Receptor Antagonists Ambrisentan, Bosentan, Macitentan, and Sitaxsentan as Hepatobiliary Transporter Inhibitors and Substrates in Sandwich-Cultured Human Hepatocytes

BACKGROUND: Inhibition of the transporter-mediated hepatobiliary elimination of bile salts is a putative mechanism for liver toxicity observed with some endothelin receptor antagonists (ERAs). METHODS: Sandwich-cultured human hepatocytes were used to study the hepatobiliary distribution and accumula...

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Autors principals: Lepist, Eve-Irene, Gillies, Hunter, Smith, William, Hao, Jia, Hubert, Cassandra, St. Claire, Robert L., Brouwer, Kenneth R., Ray, Adrian S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907537/
https://ncbi.nlm.nih.gov/pubmed/24498134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087548
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