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Prediction of Hepatic Efflux Transporter-mediated Drug Interactions: When is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?
The intracellular unbound inhibitor concentration ([I](unbound,cell)) is most relevant for predicting the inhibition of hepatic efflux transporters. However, the intracellular unbound fraction of inhibitor in hepatocytes (f(u,cell,inhibitor)) is not routinely determined. Studies are needed to evalua...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617730/ https://ncbi.nlm.nih.gov/pubmed/28465154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2017.04.054 |
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