Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro

Por Lepist, Eve-Irene, Phan, Truc K., Roy, Anupma, Tong, Leah, MacLennan, Kelly, Murray, Bernard, Ray, Adrian S.
Publicado em 2012

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat

Por Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S
Publicado em 2014

Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer

Por Xu, Lianhong, Liu, Hongtao, Murray, Bernard P., Callebaut, Christian, Lee, Melody S., Hong, Allen, Strickley, Robert G., Tsai, Luong K., Stray, Kirsten M., Wang, Yujin, Rhodes, Gerry R., Desai, Manoj C.
Publicado em 2010

In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile

Por Callebaut, Christian, Stray, Kirsten, Tsai, Luong, Williams, Matt, Yang, Zheng-Yu, Cannizzaro, Carina, Leavitt, Stephanie A., Liu, Xiaohong, Wang, Kelly, Murray, Bernard P., Mulato, Andrew, Hatada, Marcos, Priskich, Tina, Parkin, Neil, Swaminathan, Swami, Lee, William, He, Gong-Xin, Xu, Lianhong, Cihlar, Tomas
Publicado em 2011

Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors

Por Lazerwith, Scott E., Bahador, Gina, Canales, Eda, Cheng, Guofeng, Chong, Lee, Clarke, Michael O., Doerffler, Edward, Eisenberg, Eugene J., Hayes, Jaclyn, Lu, Bing, Liu, Qi, Matles, Mike, Mertzman, Michael, Mitchell, Michael L., Morganelli, Philip, Murray, Bernard P., Robinson, Margaret, Strickley, Robert G., Tessler, Megan, Tirunagari, Neeraj, Wang, Jianhong, Wang, Yujin, Zhang, Jennifer R., Zheng, Xubin, Zhong, Weidong, Watkins, William J.
Publicado em 2011

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

Por Fenaux, Martijn, Eng, Stacey, Leavitt, Stephanie A., Lee, Yu-Jen, Mabery, Eric M., Tian, Yang, Byun, Daniel, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Lazerwith, Scott E., Lew, Willard, Liu, Qi, Mertzman, Michael, Morganelli, Philip, Xu, Lianhong, Ye, Hong, Zhang, Jennifer, Matles, Mike, Murray, Bernard P., Mwangi, Judy, Zhang, Jingyu, Hashash, Ahmad, Krawczyk, Steve H., Bidgood, Alison M., Appleby, Todd C., Watkins, William J.
Publicado em 2013