In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile

GS-8374 is a novel bis-tetrahydrofuran HIV-1 protease (PR) inhibitor (PI) with a unique diethylphosphonate moiety. It was selected from a series of analogs containing various di(alkyl)phosphonate substitutions connected via a linker to the para position of a P-1 phenyl ring. GS-8374 inhibits HIV-1 P...

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Библиографические подробности
Главные авторы: Callebaut, Christian, Stray, Kirsten, Tsai, Luong, Williams, Matt, Yang, Zheng-Yu, Cannizzaro, Carina, Leavitt, Stephanie A., Liu, Xiaohong, Wang, Kelly, Murray, Bernard P., Mulato, Andrew, Hatada, Marcos, Priskich, Tina, Parkin, Neil, Swaminathan, Swami, Lee, William, He, Gong-Xin, Xu, Lianhong, Cihlar, Tomas
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2011
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067135/
https://ncbi.nlm.nih.gov/pubmed/21245449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01183-10
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