GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions

Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimental HIV PI, GS-8374, relative to that of other PIs,...

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Detalhes bibliográficos
Main Authors: Grantz Šašková, Klára, Kožíšek, Milan, Stray, Kirsten, de Jong, Dorien, Řezáčová, Pavlína, Brynda, Jiří, van Maarseveen, Noortje M., Nijhuis, Monique, Cihlář, Tomáš, Konvalinka, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957959/
https://ncbi.nlm.nih.gov/pubmed/24371077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02688-13
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