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GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions

Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimental HIV PI, GS-8374, relative to that of other PIs,...

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Detaylı Bibliyografya
Asıl Yazarlar: Grantz Šašková, Klára, Kožíšek, Milan, Stray, Kirsten, de Jong, Dorien, Řezáčová, Pavlína, Brynda, Jiří, van Maarseveen, Noortje M., Nijhuis, Monique, Cihlář, Tomáš, Konvalinka, Jan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957959/
https://ncbi.nlm.nih.gov/pubmed/24371077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02688-13
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