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GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions

Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimental HIV PI, GS-8374, relative to that of other PIs,...

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Dettagli Bibliografici
Autori principali: Grantz Šašková, Klára, Kožíšek, Milan, Stray, Kirsten, de Jong, Dorien, Řezáčová, Pavlína, Brynda, Jiří, van Maarseveen, Noortje M., Nijhuis, Monique, Cihlář, Tomáš, Konvalinka, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957959/
https://ncbi.nlm.nih.gov/pubmed/24371077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02688-13
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