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Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

Darunavir is the most recently approved human immunodeficiency virus (HIV) protease (PR) inhibitor (PI) and is active against many HIV type 1 PR variants resistant to earlier-generation PIs. Darunavir shows a high genetic barrier to resistance development, and virus strains with lower sensitivity to...

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Autori principali: Šašková, Klára Grantz, Kožíšek, Milan, Řezáčová, Pavlína, Brynda, Jiří, Yashina, Tatyana, Kagan, Ron M., Konvalinka, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738195/
https://ncbi.nlm.nih.gov/pubmed/19535439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00451-09
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