From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease

HIV protease (PR) represents a prime target for rational drug design, and protease inhibitors (PI) are powerful antiviral drugs. Most of the current PIs are pseudopeptide compounds with limited bioavailability and stability, and their use is compromised by high costs, side effects, and development o...

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Xehetasun bibliografikoak
Egile Nagusiak: Cígler, Petr, Kožíšek, Milan, Řezáčová, Pavlína, Brynda, Jíří, Otwinowski, Zbyszek, Pokorná, Jana, Plešek, Jaromír, Grüner, Bohumír, Dolečková-Marešová, Lucie, Máša, Martin, Sedláček, Juraj, Bodem, Jochen, Kräusslich, Hans-Georg, Král, Vladimír, Konvalinka, Jan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2005
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1255736/
https://ncbi.nlm.nih.gov/pubmed/16227435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507577102
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