From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease

HIV protease (PR) represents a prime target for rational drug design, and protease inhibitors (PI) are powerful antiviral drugs. Most of the current PIs are pseudopeptide compounds with limited bioavailability and stability, and their use is compromised by high costs, side effects, and development o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Cígler, Petr, Kožíšek, Milan, Řezáčová, Pavlína, Brynda, Jíří, Otwinowski, Zbyszek, Pokorná, Jana, Plešek, Jaromír, Grüner, Bohumír, Dolečková-Marešová, Lucie, Máša, Martin, Sedláček, Juraj, Bodem, Jochen, Kräusslich, Hans-Georg, Král, Vladimír, Konvalinka, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1255736/
https://ncbi.nlm.nih.gov/pubmed/16227435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507577102
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados