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Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor
HIV protease (PR) is required for proteolytic maturation in the late phase of HIV replication and represents a prime therapeutic target. The regulation and kinetics of viral polyprotein processing and maturation are currently not understood in detail. Here we design, synthesize, validate and apply a...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Pub. Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366505/ https://ncbi.nlm.nih.gov/pubmed/25751579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7461 |
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