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DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening

Human diseases are often diagnosed by determining levels of relevant enzymes and treated by enzyme inhibitors. We describe an assay suitable for both ultrasensitive enzyme quantification and quantitative inhibitor screening with unpurified enzymes. In the DNA-linked Inhibitor ANtibody Assay (DIANA),...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Navrátil, Václav, Schimer, Jiří, Tykvart, Jan, Knedlík, Tomáš, Vik, Viktor, Majer, Pavel, Konvalinka, Jan, Šácha, Pavel
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314793/
https://ncbi.nlm.nih.gov/pubmed/27679479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw853
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