iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties

Antibodies are indispensable tools for biomedicine and anticancer therapy. Nevertheless, their use is compromised by high production costs, limited stability, and difficulty of chemical modification. The design and preparation of synthetic polymer conjugates capable of replacing antibodies in biomed...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Šácha, Pavel, Knedlík, Tomáš, Schimer, Jiří, Tykvart, Jan, Parolek, Jan, Navrátil, Václav, Dvořáková, Petra, Sedlák, František, Ulbrich, Karel, Strohalm, Jiří, Majer, Pavel, Šubr, Vladimír, Konvalinka, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755222/
https://ncbi.nlm.nih.gov/pubmed/26749427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508642
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