Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

HIV protease (PR) is required for proteolytic maturation in the late phase of HIV replication and represents a prime therapeutic target. The regulation and kinetics of viral polyprotein processing and maturation are currently not understood in detail. Here we design, synthesize, validate and apply a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Schimer, Jiří, Pávová, Marcela, Anders, Maria, Pachl, Petr, Šácha, Pavel, Cígler, Petr, Weber, Jan, Majer, Pavel, Řezáčová, Pavlína, Kräusslich, Hans-Georg, Müller, Barbara, Konvalinka, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366505/
https://ncbi.nlm.nih.gov/pubmed/25751579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7461
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