Mutations in Multiple Domains of Gag Drive the Emergence of In Vitro Resistance to the Phosphonate-Containing HIV-1 Protease Inhibitor GS-8374

GS-8374 is a potent HIV protease inhibitor (PI) with a unique diethyl-phosphonate moiety. Due to a balanced contribution of enthalpic and entropic components to its interaction with the protease (PR) active site, the compound retains activity against HIV mutants with high-level multi-PI resistance....

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Detalhes bibliográficos
Main Authors: Stray, Kirsten M., Callebaut, Christian, Glass, Bärbel, Tsai, Luong, Xu, Lianhong, Müller, Barbara, Kräusslich, Hans-Georg, Cihlar, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536386/
https://ncbi.nlm.nih.gov/pubmed/23097440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01211-12
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