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Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Previous studies suggested a principal role for the lysosomal serine protease cathepsin A (CatA) in the intracellular activation of TAF. Here we further inv...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704186/ https://ncbi.nlm.nih.gov/pubmed/26503655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01834-15 |
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