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Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Previous studies suggested a principal role for the lysosomal serine protease cathepsin A (CatA) in the intracellular activation of TAF. Here we further inv...
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| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704186/ https://ncbi.nlm.nih.gov/pubmed/26503655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01834-15 |
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