Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors

Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Previous studies suggested a principal role for the lysosomal serine protease cathepsin A (CatA) in the intracellular activation of TAF. Here we further inv...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Birkus, Gabriel, Bam, Rujuta A., Willkom, Madeleine, Frey, Christian R., Tsai, Luong, Stray, Kirsten M., Yant, Stephen R., Cihlar, Tomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704186/
https://ncbi.nlm.nih.gov/pubmed/26503655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01834-15
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