TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells

GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV expression ex vivo in latently infected peripheral bl...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Bam, Rujuta A., Hansen, Derek, Irrinki, Alivelu, Mulato, Andrew, Jones, Gregg S., Hesselgesser, Joseph, Frey, Christian R., Cihlar, Tomas, Yant, Stephen R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192112/
https://ncbi.nlm.nih.gov/pubmed/27799218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01369-16
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