Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors

Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Previous studies suggested a principal role for the lysosomal serine protease cathepsin A (CatA) in the intracellular activation of TAF. Here we further inv...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Birkus, Gabriel, Bam, Rujuta A., Willkom, Madeleine, Frey, Christian R., Tsai, Luong, Stray, Kirsten M., Yant, Stephen R., Cihlar, Tomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704186/
https://ncbi.nlm.nih.gov/pubmed/26503655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01834-15
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