Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer

[Image: see text] Cobicistat (3, GS-9350) is a newly discovered, potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes. In contrast to ritonavir, 3 is devoid of anti-HIV activity and is thus more suitable for use in boosting anti-HIV drugs without risking selection of potential...

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Päätekijät: Xu, Lianhong, Liu, Hongtao, Murray, Bernard P., Callebaut, Christian, Lee, Melody S., Hong, Allen, Strickley, Robert G., Tsai, Luong K., Stray, Kirsten M., Wang, Yujin, Rhodes, Gerry R., Desai, Manoj C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2010
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007915/
https://ncbi.nlm.nih.gov/pubmed/24900196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000257
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