Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors

[Image: see text] A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochemical properties and PK were identified and exploited to guide the design of compounds. In addition, a simpl...

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Detalhes bibliográficos
Main Authors: Lazerwith, Scott E., Bahador, Gina, Canales, Eda, Cheng, Guofeng, Chong, Lee, Clarke, Michael O., Doerffler, Edward, Eisenberg, Eugene J., Hayes, Jaclyn, Lu, Bing, Liu, Qi, Matles, Mike, Mertzman, Michael, Mitchell, Michael L., Morganelli, Philip, Murray, Bernard P., Robinson, Margaret, Strickley, Robert G., Tessler, Megan, Tirunagari, Neeraj, Wang, Jianhong, Wang, Yujin, Zhang, Jennifer R., Zheng, Xubin, Zhong, Weidong, Watkins, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018142/
https://ncbi.nlm.nih.gov/pubmed/24900257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200163b
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