Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors

[Image: see text] A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochemical properties and PK were identified and exploited to guide the design of compounds. In addition, a simpl...

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Bibliografski detalji
Glavni autori: Lazerwith, Scott E., Bahador, Gina, Canales, Eda, Cheng, Guofeng, Chong, Lee, Clarke, Michael O., Doerffler, Edward, Eisenberg, Eugene J., Hayes, Jaclyn, Lu, Bing, Liu, Qi, Matles, Mike, Mertzman, Michael, Mitchell, Michael L., Morganelli, Philip, Murray, Bernard P., Robinson, Margaret, Strickley, Robert G., Tessler, Megan, Tirunagari, Neeraj, Wang, Jianhong, Wang, Yujin, Zhang, Jennifer R., Zheng, Xubin, Zhong, Weidong, Watkins, William J.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2011
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018142/
https://ncbi.nlm.nih.gov/pubmed/24900257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200163b
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