Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

GS-9669 is a highly optimized thumb site II nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, with a binding affinity of 1.35 nM for the genotype (GT) 1b protein. It is a selective inhibitor of HCV RNA replication, with a mean 50% effective concentration (EC(50)) of ≤11 nM in ge...

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Main Authors: Fenaux, Martijn, Eng, Stacey, Leavitt, Stephanie A., Lee, Yu-Jen, Mabery, Eric M., Tian, Yang, Byun, Daniel, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Lazerwith, Scott E., Lew, Willard, Liu, Qi, Mertzman, Michael, Morganelli, Philip, Xu, Lianhong, Ye, Hong, Zhang, Jennifer, Matles, Mike, Murray, Bernard P., Mwangi, Judy, Zhang, Jingyu, Hashash, Ahmad, Krawczyk, Steve H., Bidgood, Alison M., Appleby, Todd C., Watkins, William J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553741/
https://ncbi.nlm.nih.gov/pubmed/23183437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02052-12
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