Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

GS-9669 is a highly optimized thumb site II nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, with a binding affinity of 1.35 nM for the genotype (GT) 1b protein. It is a selective inhibitor of HCV RNA replication, with a mean 50% effective concentration (EC(50)) of ≤11 nM in ge...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Fenaux, Martijn, Eng, Stacey, Leavitt, Stephanie A., Lee, Yu-Jen, Mabery, Eric M., Tian, Yang, Byun, Daniel, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Lazerwith, Scott E., Lew, Willard, Liu, Qi, Mertzman, Michael, Morganelli, Philip, Xu, Lianhong, Ye, Hong, Zhang, Jennifer, Matles, Mike, Murray, Bernard P., Mwangi, Judy, Zhang, Jingyu, Hashash, Ahmad, Krawczyk, Steve H., Bidgood, Alison M., Appleby, Todd C., Watkins, William J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2013
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553741/
https://ncbi.nlm.nih.gov/pubmed/23183437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02052-12
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia