Effects of Human Immunodeficiency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro

Human immunodeficiency virus protease inhibitors (PIs) modestly affect the plasma pharmacokinetics of tenofovir (TFV; −15% to +37% change in exposure) following coadministration with the oral prodrug TFV disoproxil fumarate (TDF) by a previously undefined mechanism. TDF permeation was found to be re...

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Detalhes bibliográficos
Main Authors: Tong, Leah, Phan, Truc K., Robinson, Kelly L., Babusis, Darius, Strab, Robert, Bhoopathy, Siddhartha, Hidalgo, Ismael J., Rhodes, Gerald R., Ray, Adrian S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043290/
https://ncbi.nlm.nih.gov/pubmed/17664327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00671-07
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