Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis

Intravaginal rings releasing tenofovir (TFV) or its prodrug, tenofovir disoproxil fumarate (TDF), are being evaluated for HIV and herpes simplex virus (HSV) prevention. The current studies were designed to determine the mechanisms of drug accumulation in human vaginal and immune cells. The exposure...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Taneva, Ekaterina, Crooker, Kerry, Park, Sung Hyun, Su, Jonathan T., Ott, Adina, Cheshenko, Natalia, Szleifer, Igal, Kiser, Patrick F., Frank, Bruce, Mesquita, Pedro M. M., Herold, Betsy C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
Onderwerpen:
Antiviral Agents
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775922/
https://ncbi.nlm.nih.gov/pubmed/26711762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02793-15
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