Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis

Intravaginal rings releasing tenofovir (TFV) or its prodrug, tenofovir disoproxil fumarate (TDF), are being evaluated for HIV and herpes simplex virus (HSV) prevention. The current studies were designed to determine the mechanisms of drug accumulation in human vaginal and immune cells. The exposure...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Taneva, Ekaterina, Crooker, Kerry, Park, Sung Hyun, Su, Jonathan T., Ott, Adina, Cheshenko, Natalia, Szleifer, Igal, Kiser, Patrick F., Frank, Bruce, Mesquita, Pedro M. M., Herold, Betsy C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775922/
https://ncbi.nlm.nih.gov/pubmed/26711762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02793-15
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