Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis

Intravaginal rings releasing tenofovir (TFV) or its prodrug, tenofovir disoproxil fumarate (TDF), are being evaluated for HIV and herpes simplex virus (HSV) prevention. The current studies were designed to determine the mechanisms of drug accumulation in human vaginal and immune cells. The exposure...

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書目詳細資料
發表在:Antimicrob Agents Chemother
Main Authors: Taneva, Ekaterina, Crooker, Kerry, Park, Sung Hyun, Su, Jonathan T., Ott, Adina, Cheshenko, Natalia, Szleifer, Igal, Kiser, Patrick F., Frank, Bruce, Mesquita, Pedro M. M., Herold, Betsy C.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2016
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775922/
https://ncbi.nlm.nih.gov/pubmed/26711762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02793-15
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