Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis

Intravaginal rings releasing tenofovir (TFV) or its prodrug, tenofovir disoproxil fumarate (TDF), are being evaluated for HIV and herpes simplex virus (HSV) prevention. The current studies were designed to determine the mechanisms of drug accumulation in human vaginal and immune cells. The exposure...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Taneva, Ekaterina, Crooker, Kerry, Park, Sung Hyun, Su, Jonathan T., Ott, Adina, Cheshenko, Natalia, Szleifer, Igal, Kiser, Patrick F., Frank, Bruce, Mesquita, Pedro M. M., Herold, Betsy C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775922/
https://ncbi.nlm.nih.gov/pubmed/26711762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02793-15
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