Compared to Subcutaneous Tenofovir, Oral Tenofovir Disoproxyl Fumarate Administration Preferentially Concentrates the Drug into Gut-Associated Lymphoid Cells in Simian Immunodeficiency Virus-Infected Macaques

To compare tissue-based pharmacokinetics and efficacy of oral tenofovir disoproxyl fumarate (TDF) versus subcutaneous tenofovir (TFV), macaques were treated for 2 weeks starting 1 week after simian immunodeficiency virus inoculation. Despite lower plasma TFV levels in the oral TDF arm, similar TFV d...

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Main Authors: Van Rompay, Koen K. A., Babusis, Darius, Abbott, Zachary, Geng, Yongzhi, Jayashankar, Kartika, Johnson, Jeffrey A., Lipscomb, Jonathan, Heneine, Walid, Abel, Kristina, Ray, Adrian S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421865/
https://ncbi.nlm.nih.gov/pubmed/22777046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01095-12
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