Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

BACKGROUND: We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some anim...

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Main Authors: Van Rompay, Koen K A, Trott, Kristin A, Jayashankar, Kartika, Geng, Yongzhi, LaBranche, Celia C, Johnson, Jeffrey A, Landucci, Gary, Lipscomb, Jonathan, Tarara, Ross P, Canfield, Don R, Heneine, Walid, Forthal, Donald N, Montefiori, David, Abel, Kristina
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419085/
https://ncbi.nlm.nih.gov/pubmed/22805180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-57
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