Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

BACKGROUND: We reported previously on the emergence and clinical implications of simian immunodeficiency virus (SIVmac251) mutants with a K65R mutation in reverse transcriptase (RT), and the role of CD8+ cell-mediated immune responses in suppressing viremia during tenofovir therapy. Because of signi...

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Detalhes bibliográficos
Main Authors: Van Rompay, Koen KA, Johnson, Jeffrey A, Blackwood, Emily J, Singh, Raman P, Lipscomb, Jonathan, Matthews, Timothy B, Marthas, Marta L, Pedersen, Niels C, Bischofberger, Norbert, Heneine, Walid, North, Thomas W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852805/
https://ncbi.nlm.nih.gov/pubmed/17417971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-25
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