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Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

BACKGROUND: We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some anim...

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Dettagli Bibliografici
Autori principali: Van Rompay, Koen K A, Trott, Kristin A, Jayashankar, Kartika, Geng, Yongzhi, LaBranche, Celia C, Johnson, Jeffrey A, Landucci, Gary, Lipscomb, Jonathan, Tarara, Ross P, Canfield, Don R, Heneine, Walid, Forthal, Donald N, Montefiori, David, Abel, Kristina
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419085/
https://ncbi.nlm.nih.gov/pubmed/22805180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-57
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