Novel Nucleotide Human Immunodeficiency Virus Reverse Transcriptase Inhibitor GS-9148 with a Low Nephrotoxic Potential: Characterization of Renal Transport and Accumulation

Accumulation of antiviral nucleotides in renal proximal tubules is controlled by their basolateral uptake via the human renal organic anion transporters type 1 (hOAT1) and 3 (hOAT3) and apical efflux via the multidrug resistance protein 4 (MRP4). GS-9148 is a novel ribose-modified nucleotide human i...

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Main Authors: Cihlar, Tomas, LaFlamme, Genevieve, Fisher, Robyn, Carey, Anne C., Vela, Jennifer E., Mackman, Richard, Ray, Adrian S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612154/
https://ncbi.nlm.nih.gov/pubmed/19001108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01183-08
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