Novel Nucleotide Human Immunodeficiency Virus Reverse Transcriptase Inhibitor GS-9148 with a Low Nephrotoxic Potential: Characterization of Renal Transport and Accumulation

Por Cihlar, Tomas, LaFlamme, Genevieve, Fisher, Robyn, Carey, Anne C., Vela, Jennifer E., Mackman, Richard, Ray, Adrian S.
Publicado em 2009

Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent

Por Ray, Adrian S., Vela, Jennifer E., Boojamra, Constantine G., Zhang, Lijun, Hui, Hon, Callebaut, Christian, Stray, Kirsten, Lin, Kuei-Ying, Gao, Ying, Mackman, Richard L., Cihlar, Tomas
Publicado em 2008

GS-5806 Inhibits Pre- to Postfusion Conformational Changes of the Respiratory Syncytial Virus Fusion Protein

Por Samuel, Dharmaraj, Xing, Weimei, Niedziela-Majka, Anita, Wong, Jinny S., Hung, Magdeleine, Brendza, Katherine M., Perron, Michel, Jordan, Robert, Sperandio, David, Liu, Xiaohong, Mackman, Richard, Sakowicz, Roman
Publicado no Antimicrob Agents Chemother (2015)

GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process

Por Perron, Michel, Stray, Kirsten, Kinkade, April, Theodore, Dorothy, Lee, Gary, Eisenberg, Eugene, Sangi, Michael, Gilbert, Brian E., Jordan, Robert, Piedra, Pedro A., Toms, Geoffery L., Mackman, Richard, Cihlar, Tomas
Publicado no Antimicrob Agents Chemother (2016)

Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection

Por Jordan, Robert, Shao, Matt, Mackman, Richard L., Perron, Michel, Cihlar, Tomas, Lewis, Sandy A., Eisenberg, Eugene J., Carey, Anne, Strickley, Robert G., Chien, Jason W., Anderson, Mark L., McEligot, Heather A., Behrens, Nicole E., Gershwin, Laurel J.
Publicado no Antimicrob Agents Chemother (2015)

Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphon...

Por Cihlar, Tomas, Ray, Adrian S., Boojamra, Constantine G., Zhang, Lijun, Hui, Hon, Laflamme, Genevieve, Vela, Jennifer E., Grant, Deborah, Chen, James, Myrick, Florence, White, Kirsten L., Gao, Ying, Lin, Kuei-Ying, Douglas, Janet L., Parkin, Neil T., Carey, Anne, Pakdaman, Rowchanak, Mackman, Richard L.
Publicado em 2008

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

Por Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.
Publicado no Sci Rep (2017)

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Por Sheahan, Timothy P., Sims, Amy C., Graham, Rachel L., Menachery, Vineet D., Gralinski, Lisa E., Case, James B., Leist, Sarah R., Pyrc, Krzysztof, Feng, Joy Y., Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O., Mackman, Richard L., Spahn, Jamie E., Palmiotti, Christopher A., Siegel, Dustin, Ray, Adrian S., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.
Publicado no Sci Transl Med (2017)

Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential

Por Jordan, Robert, Hogg, Alison, Warren, Travis, De Wit, Emmie, Sheahan, Timothy, Lo, Michael, Soloveva, Veronica, Weidner, Jessica, Gomba, Laura, Feldmann, Friederike, Cronin, Jacqueline, Sims, Amy, Cockrell, Adam, Feng, Joy, Trantcheva, Iva, Babusis, Darius, Porter-Poulin, Danielle, Bannister, Roy, Mackman, Richard, Siegel, Dustin, Ray, Adrian, Denison, Mark, Spiropoulou, Christina, Nichol, Stuart, Cihlar, Tomas, Baric, Ralph, Feldmann, Heinrich, Bavari, Sina
Publicado no Open Forum Infect Dis (2017)

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Por Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina
Publicado no Nature (2016)