SYNTHESIS OF ETHYL (1S,2R,3S,4S,5S)-2,3-O-(ISOPROPYLIDENE)-4-HYDROXY-BICYCLO[3.1.0]HEXANE-CARBOXYLATE FROM L-RIBOSE: A VERSATILE CHIRAL SYNTHON FOR PREPARATION OF ADENOSINE AND P2...

Tekijä Joshi, Bhalchandra V., Melman, Artem, Mackman, Richard L., Jacobson, Kenneth A.
Julkaisussa Nucleosides Nucleotides Nucleic Acids (2008)

Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent

Tekijä Ray, Adrian S., Vela, Jennifer E., Boojamra, Constantine G., Zhang, Lijun, Hui, Hon, Callebaut, Christian, Stray, Kirsten, Lin, Kuei-Ying, Gao, Ying, Mackman, Richard L., Cihlar, Tomas
Julkaistu 2008

Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection

Tekijä Jordan, Robert, Shao, Matt, Mackman, Richard L., Perron, Michel, Cihlar, Tomas, Lewis, Sandy A., Eisenberg, Eugene J., Carey, Anne, Strickley, Robert G., Chien, Jason W., Anderson, Mark L., McEligot, Heather A., Behrens, Nicole E., Gershwin, Laurel J.
Julkaisussa Antimicrob Agents Chemother (2015)

Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphon...

Tekijä Cihlar, Tomas, Ray, Adrian S., Boojamra, Constantine G., Zhang, Lijun, Hui, Hon, Laflamme, Genevieve, Vela, Jennifer E., Grant, Deborah, Chen, James, Myrick, Florence, White, Kirsten L., Gao, Ying, Lin, Kuei-Ying, Douglas, Janet L., Parkin, Neil T., Carey, Anne, Pakdaman, Rowchanak, Mackman, Richard L.
Julkaistu 2008

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

Tekijä Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.
Julkaisussa Sci Rep (2017)

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Tekijä Agostini, Maria L., Andres, Erica L., Sims, Amy C., Graham, Rachel L., Sheahan, Timothy P., Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y., Jordan, Robert, Ray, Adrian S., Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L., Clarke, Michael O., Baric, Ralph S., Denison, Mark R.
Julkaisussa mBio (2018)

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Tekijä Sheahan, Timothy P., Sims, Amy C., Graham, Rachel L., Menachery, Vineet D., Gralinski, Lisa E., Case, James B., Leist, Sarah R., Pyrc, Krzysztof, Feng, Joy Y., Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O., Mackman, Richard L., Spahn, Jamie E., Palmiotti, Christopher A., Siegel, Dustin, Ray, Adrian S., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.
Julkaisussa Sci Transl Med (2017)

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Tekijä Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina
Julkaisussa Nature (2016)