Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development of antiviral nucleosides due to its proofreading activity. We recently reported that the nucleoside analogue GS-5734 (remdesivir)...

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Détails bibliographiques
Publié dans:mBio
Auteurs principaux: Agostini, Maria L., Andres, Erica L., Sims, Amy C., Graham, Rachel L., Sheahan, Timothy P., Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y., Jordan, Robert, Ray, Adrian S., Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L., Clarke, Michael O., Baric, Ralph S., Denison, Mark R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844999/
https://ncbi.nlm.nih.gov/pubmed/29511076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00221-18
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