Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Emerging viral infections are difficult to control as heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the development of specific antiviral therapies and vaccines. Coronaviruses (CoVs) have a proclivity to spread rapidly into new host species causing se...

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Pubblicato in:Sci Transl Med
Autori principali: Sheahan, Timothy P., Sims, Amy C., Graham, Rachel L., Menachery, Vineet D., Gralinski, Lisa E., Case, James B., Leist, Sarah R., Pyrc, Krzysztof, Feng, Joy Y., Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O., Mackman, Richard L., Spahn, Jamie E., Palmiotti, Christopher A., Siegel, Dustin, Ray, Adrian S., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567817/
https://ncbi.nlm.nih.gov/pubmed/28659436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal3653
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