Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential

BACKGROUND: Recent viral outbreaks with significant mortality such as Ebola virus (EBOV), SARS-coronavirus (CoV), and MERS-CoV reinforced the need for effective antiviral therapeutics to control future epidemics. GS-5734 is a novel nucleotide analog prodrug in the development for treatment of EBOV....

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Publicado no:Open Forum Infect Dis
Main Authors: Jordan, Robert, Hogg, Alison, Warren, Travis, De Wit, Emmie, Sheahan, Timothy, Lo, Michael, Soloveva, Veronica, Weidner, Jessica, Gomba, Laura, Feldmann, Friederike, Cronin, Jacqueline, Sims, Amy, Cockrell, Adam, Feng, Joy, Trantcheva, Iva, Babusis, Darius, Porter-Poulin, Danielle, Bannister, Roy, Mackman, Richard, Siegel, Dustin, Ray, Adrian, Denison, Mark, Spiropoulou, Christina, Nichol, Stuart, Cihlar, Tomas, Baric, Ralph, Feldmann, Heinrich, Bavari, Sina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630887/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx180.008
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