Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations

The coronavirus (CoV) RNA genome is the largest among the single-stranded positive-sense RNA viruses. CoVs encode a proofreading 3′-to-5′ exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is responsible for CoV high-fidelity replication. Alanine substitution of ExoN catalytic residue...

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Udgivet i:mBio
Main Authors: Graepel, Kevin W., Lu, Xiaotao, Case, James Brett, Sexton, Nicole R., Smith, Everett Clinton, Denison, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676041/
https://ncbi.nlm.nih.gov/pubmed/29114026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01503-17
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