GS-5806 Inhibits Pre- to Postfusion Conformational Changes of the Respiratory Syncytial Virus Fusion Protein

GS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral envelope with the host cell membrane. This process is reproduced in vitro us...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Samuel, Dharmaraj, Xing, Weimei, Niedziela-Majka, Anita, Wong, Jinny S., Hung, Magdeleine, Brendza, Katherine M., Perron, Michel, Jordan, Robert, Sperandio, David, Liu, Xiaohong, Mackman, Richard, Sakowicz, Roman
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2015
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604407/
https://ncbi.nlm.nih.gov/pubmed/26324264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00761-15
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