GS-5806 Inhibits Pre- to Postfusion Conformational Changes of the Respiratory Syncytial Virus Fusion Protein

GS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral envelope with the host cell membrane. This process is reproduced in vitro us...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Samuel, Dharmaraj, Xing, Weimei, Niedziela-Majka, Anita, Wong, Jinny S., Hung, Magdeleine, Brendza, Katherine M., Perron, Michel, Jordan, Robert, Sperandio, David, Liu, Xiaohong, Mackman, Richard, Sakowicz, Roman
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604407/
https://ncbi.nlm.nih.gov/pubmed/26324264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00761-15
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