Mechanism of Resistance to GS-9148 Conferred by the Q151L Mutation in HIV-1 Reverse Transcriptase

GS-9148 is an investigational phosphonate nucleotide analogue inhibitor of reverse transcriptase (RT) (NtRTI) of human immunodeficiency virus type 1 (HIV-1). This compound is an adenosine derivative with a 2′,3′-dihydrofuran ring structure that contains a 2′-fluoro group. The resistance profile of G...

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Detalhes bibliográficos
Main Authors: Scarth, Brian J., White, Kirsten L., Chen, James M., Lansdon, Eric B., Swaminathan, S., Miller, Michael D., Götte, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101450/
https://ncbi.nlm.nih.gov/pubmed/21402840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01738-10
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