Molecular Mechanisms of Tenofovir Resistance Conferred by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing a Diserine Insertion after Residue 69 and Multiple Thymidine Analog-Associated Mutations

Two amino acids inserted between residues 69 and 70 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are rare mutations that may develop in viruses containing multiple thymidine analog (zidovudine [AZT], stavudine)-associated mutations and that confer high-level resistance t...

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Main Authors: White, Kirsten L., Chen, James M., Margot, Nicolas A., Wrin, Terri, Petropoulos, Christos J., Naeger, Lisa K., Swaminathan, S., Miller, Michael D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2004
Ábhair:
Antiviral Agents
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC353090/
https://ncbi.nlm.nih.gov/pubmed/14982794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.3.992-1003.2004
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