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Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy

Tenofovir alafenamide (TAF) is a prodrug of tenofovir (TFV) currently in clinical evaluation for treatment for HIV and hepatitis B virus (HBV) infections. Since the target tissue for HBV is the liver, the hepatic delivery and metabolism of TAF in primary human hepatocytes in vitro and in dogs in viv...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Murakami, Eisuke, Wang, Ting, Park, Yeojin, Hao, Jia, Lepist, Eve-Irene, Babusis, Darius, Ray, Adrian S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432166/
https://ncbi.nlm.nih.gov/pubmed/25870059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00128-15
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