Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

PSI-352938 is a novel cyclic phosphate prodrug of β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methylguanosine 5′-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with ot...

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Главные авторы: Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, Zennou, Veronique, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Keilman, Meg, Bao, Haiying, Bourne, Nigel, Veselenak, Ronald L., Reddy, P. Ganapati, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101412/
https://ncbi.nlm.nih.gov/pubmed/21444700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00032-11
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