Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

PSI-352938 is a novel cyclic phosphate prodrug of β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methylguanosine 5′-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with ot...

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מידע ביבליוגרפי
Main Authors: Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, Zennou, Veronique, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Keilman, Meg, Bao, Haiying, Bourne, Nigel, Veselenak, Ronald L., Reddy, P. Ganapati, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2011
נושאים:
Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101412/
https://ncbi.nlm.nih.gov/pubmed/21444700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00032-11
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