Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

PSI-352938 is a novel cyclic phosphate prodrug of β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methylguanosine 5′-monophosphate that has potent activity against hepatitis C virus (HCV) in vitro. The studies described here characterize the in vitro anti-HCV activity of PSI-352938, alone and in combination with ot...

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Detaylı Bibliyografya
Asıl Yazarlar: Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, Zennou, Veronique, Bansal, Shalini, Micolochick Steuer, Holly M., Niu, Congrong, Keilman, Meg, Bao, Haiying, Bourne, Nigel, Veselenak, Ronald L., Reddy, P. Ganapati, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Sofia, Michael J., Otto, Michael J., Furman, Phillip A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2011
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101412/
https://ncbi.nlm.nih.gov/pubmed/21444700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00032-11
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