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Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

PSI-352938, a cyclic phosphate nucleotide, and PSI-353661, a phosphoramidate nucleotide, are prodrugs of β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methylguanosine-5′-monophosphate. Both compounds are metabolized to the same active 5′-triphosphate, PSI-352666, which serves as an alternative substrate inhibitor...

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Autori principali: Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M., Zennou, Veronique, Otto, Michael J., Furman, Phillip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209386/
https://ncbi.nlm.nih.gov/pubmed/21957306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05639-11
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