Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA

Lignende værker

• Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
  af: Lam, Angela M., et al.
  Udgivet: (2011)
• Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
  af: Lam, Angela M., et al.
  Udgivet: (2012)
• Activity and the Metabolic Activation Pathway of the Potent and Selective Hepatitis C Virus Pronucleotide Inhibitor PSI-353661
  af: Furman, Phillip A., et al.
  Udgivet: (2011)
• Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection
  af: Chang, Wonsuk, et al.
  Udgivet: (2010)
• Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938
  af: Niu, Congrong, et al.
  Udgivet: (2012)